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A 14 Day Recovery Period Reverses the Decline in Lifelong Physical Activity Following a Significant Ankle Sprain
Author(s) -
HubbardTurner Tricia,
Wikstrom Erik A,
Turner Michael J
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.1020.17
Subject(s) - medicine , ankle , analysis of variance , physical activity , sham surgery , quartile , ankle sprain , anesthesia , surgery , physical therapy , confidence interval , alternative medicine , pathology
We have previously shown a decrease in lifelong physical activity following a significant ankle sprain in mice. To investigate the impact of a prolonged rest period on lifelong activity, at seven weeks of age we transected the CFL and ATFL of the right hindlimb in six male CBA/J mice and conducted a SHAM surgery on 10 male CBA/J mice. The SHAM mice were placed in separate cages with a running wheel immediately post‐surgery while the ankle sprain (AS) mice were placed in separate cages but exposed to a running wheel 14 days post‐surgery to allow for tissue healing. Physical activity was measured daily from eight weeks until 52 weeks of age (72% of lifespan). Daily duration, distance and running speed were analyzed by ANOVA (Group × Time) with repeated measures (p<0.05) at 15‐week periods to approximate the first three quartiles of lifespan. From weeks three to 15 post‐surgery, duration and distance were not different between groups but the running speed was faster for the SHAM mice (p=0.009). No differences were observed between groups for duration, distance or running speed from weeks 16 to 30 or 31 to 45 post‐surgery (p>0.05). Additionally, duration, distance, and running speed did not significantly change across/among the 15‐week periods. These findings suggest the commonly observed decline in physical activity throughout the lifespan following an ankle sprain can be restored to non‐injured levels with the incorporation of a 14 day rest period in mice. Support or Funding Information Supported by UNC Charlotte Faculty Research Grants (Hubbard‐Turner, Wikstrom, and Turner)