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Chronic E‐Cigarette Usage on Blood Glucose
Author(s) -
Hoskinson Hannah Nicole,
Breit Matthew,
Pitzer Christopher,
Wu Zhong X,
Olfert I M,
Bryner Randy
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.1014.18
Subject(s) - medicine , bolus (digestion) , nicotine , insulin resistance , insulin , zoology , food science , chemistry , biology
Traditional cigarette usage has been linked to a number of nefarious metabolic effects, including insulin resistance, however the effects of electronic cigarettes (E‐cigs) are not currently known. Advertised as a safe alternative for traditional tobacco cigarettes, long‐term studies investigating the metabolic effects of E‐cigs are lacking. The purpose of this study was to gain a better understanding of the possible metabolic consequences of E‐cig usage. We hypothesize E‐cig usage will induce insulin resistance in mice. Methods C57BL/6 mice were divided between E‐cig (n=13) and control (n=13) groups and exposed to either vaporized cappuccino flavored E‐cig liquid (18 mg/mL nicotine) or filtered air for 4h/d, 5 d/wk for 6 months. Fasting blood glucose (FBG) and glucose tolerance (GTT) were assessed following an overnight fast. A glucose bolus was administered via gelatin pellet (3g glucose/kg) which was ingested within 2 min. Blood was collected by tail nick and glucose measured using Bayer Contour glucometer and test strips. Results After 6 months exposure, total body mass (28.1 ±3.2g vs 27.3 ±3.1g) and lean body mass (18.71 ±0.25g vs 18.38 ±0.27g) were similar between E‐cig and air exposed groups, respectively. Likewise, E‐cig exposure did not result in significant difference in FBG (128. ±35mg/dL vs 120 ±33mg/dL), GTT 0‐120 , and peak glucose response (174 ±6mg/dL vs 159 ±6mg/dL, p=0.08). However for GTT 0‐30 there was a significant interaction for glucose response between the groups (p=0.05). Conclusion These results suggest there may be some initial differences in glucose response in animals exposed to E‐cigs when compared to controls, however FBG and overall glucose handling was not significantly different between the groups. Future studies are needed to determine if greater levels of nicotine exposure via E‐cigs contribute to impairment of glucose metabolism. Support or Funding Information NIH Grant P20GM103434 (West Virginia IDeA Network for Biomedical Research Excellence) and Marshall‐WVU Health Initiative Award