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Glucocorticoid Sensitivity and Systolic Blood Pressure During Graded Submaximal Exercise
Author(s) -
Del Corral Pedro,
Mancol Faith Laureen V,
DePasquale John,
Haug Andrew,
Teelucksingh Surujpal
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.1012.1
Subject(s) - glucocorticoid , medicine , blood pressure , endocrinology , cardiology
Background The exaggerated systolic blood pressure (SBP) response to exercise predicts future hypertension and coronary artery disease. Hypertension has been associated to an increase in glucocorticoid sensitivity. Little is known about the effects of glucocorticoid sensitivity on the exaggerated SBP response to submaximal exercise. PURPOSE The aim of this study was to examine the relationship between glucocorticoid sensitivity and the systolic blood pressure response to graded submaximal exercise (GSE) on a cycle ergometer. METHODS Twenty two (19M, 3F) non‐hypertensive subjects (111.3/64.3 mmHg ± 1.9/1.4) underwent the dermal vasoconstrictor assay, using beclomethasone dipropionate, to determine glucocorticoid sensitivity, and subjects completed the GSE test with serial SBP measurements. Pearson's correlations were used to examine the relationship between glucocorticoid sensitivity and peak‐SBP. Subjects were dichotomized for glucocorticoid sensitivity, the upper and lower tertiles (11.4 ± 0.8 vs 3.2 ± 0.8, respectively; p<0.05) were compared for peak SBP during GSE and for rest to peak‐BP (Δ‐SBP). RESULTS There was a moderate association between dermal glucocorticoid sensitivity and peak SBP (r = 0.550, p<0.05), and Δ‐SBP (r = 0.497, p<0.05). Subjects on the upper tertile for glucocorticoid sensitivity had significantly higher peak SBP (189.2 ± 5.6 mmHg vs 155.5 ± 5.2 mmHg, p<0.05) and Δ‐SBP (76.9 ± 5.9 mmHg vs 48.2 ± 5.0 mmHg, p<0.05), compared to subjects on the lower tertile. CONCLUSIONS These findings suggest that individuals with a high glucocorticoid sensitivity, as suggested by the dermal vasoconstrictor assay SCORE, have a greater submaximal exercise peak SBP and Δ‐SBP, compared to those with a low glucocorticoid sensitivity. Support or Funding Information Benedictine University Summer Research Program