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Beneficial renal effect of multi‐glycoside of Tripterygium wilfordii Hook. F. in mice with salt‐sensitive hypertension
Author(s) -
Wang Youping,
Zhu Minjun,
Wang Zhentao,
Cui Lin,
Liu Suxiao,
Xie Shiyan,
Shen Si,
Xu Hui
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.1011.8
Subject(s) - tripterygium wilfordii , medicine , endocrinology , hydroxyproline , renal hypertrophy , tripterygium , chemistry , kidney , glycoside , pathology , alternative medicine , organic chemistry , diabetic nephropathy
To clarify the effects of low‐dose of multi‐glycoside of Tripterygium wilfordii Hook. F. (GTW), an extract from a Chinese herb thunder god vine, on salt‐sensitive hypertension‐induced renal damage, we induced hypertension by uninephrectomy and deoxycorticosterone (DOCA)‐salt in mice with or without low‐dose of GTW treatment. DOCA‐salt treatment for 5 weeks increased mean arterial pressure (MAP) ( P <0.01) and urinary albumin excretion ( P <0.05), and also induced renal hypertrophy ( P <0.01) compared with the control. Periodic acid‐Schiff and Masson's trichrome staining showed that DOCA‐salt treatment caused obvious glomerulosclrosis and tubulointerstitial injury in the renal cortex ( P <0.05), and tubulointerstitial fibrosis compared with the control mice. Consistent with the results, renal collagen level determined using hydroxyproline assay was higher in DOCA‐salt‐treated mice compared with the control mice ( P <0.05). Treatment with GTW at the low dose of 11.5 mg/kg/day by gavage had no effect on MAP and renal hypertrophy. However, it partially prevented renal morphological damage and reduced the increases in urinary albumin excretion and renal collagen ( P <0.05). Our data showed that treatment with the low dose of GTW prevented renal damage induced by DOCA‐salt hypertension independently of their effects on blood pressure. The results indicate that low‐dose of GTW exhibits a protective effect on renal damage during salt‐sensitive hypertension. This work was supported in part by the National Natural Science Foundation of China (No. 81673734) and Henan Provincial Science and Technique Foundation for International Cooperation Program (No. 162102410048) Support or Funding Information This work was supported in part by the National Natural Science Foundation of China (No. 81673734) and Henan Provincial Science and Technique Foundation for International Cooperation Program (No. 162102410048)