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Hypertension is accompanied with over‐activity of immunity
Author(s) -
Shen Xiao Gregory Z.,
Zhao Tuantuan,
Shi Peng,
Bernstein Kenneth E.
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.1011.1
Subject(s) - ovalbumin , immune system , angiotensin ii , genetically modified mouse , immunology , immunity , antigen , medicine , transgene , endocrinology , acquired immune system , cd8 , spleen , biology , blood pressure , biochemistry , gene
Immune system plays an important role in the pathogenesis of hypertension. To understand whether hypertension affects immunity, we studied antigen presenting cells (APCs) isolated from mice with hypertension induced by angiotensin II or L‐NAME. The APCs derived from hypertensive mice were superior in presenting antigens in vitro. To study antigen presentation in vivo, we immunized sham and AngII treated wild type mice with ovalbumin. Consistently, more OVA‐specific CD8 + T cells were induced in the blood and the spleen of hypertensive mice. Moreover, RIP‐mOVA mice were studied because this transgenic mouse line expressing membrane‐bound OVA in pancreatic islet β cells. RIP‐mOVA mice were made hypertensive with either angiotensin II or L‐NAME. When OVA‐specific OT‐I T cells were i.v. infused into RIP‐mOVA mice, the hypertensive mice had more OT‐I cells infiltration into the pancreas and they developed diabetes more rapidly. These data suggest that hypertension itself is associated with over‐activity of the adaptive immune system. Support or Funding Information National Nature Science Foudation of China 31270950 and 81670378