Premium
Correlation between beta‐arrestin1 and prolactin levels in women with depression during premenstrual dysphoric disorder
Author(s) -
Smith Keisha,
Archibong Anthony E,
Ansah Twum A,
Nayyar Tultul
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.31.1_supplement.1000.7
Subject(s) - premenstrual dysphoric disorder , prolactin , medicine , depression (economics) , endocrinology , luteal phase , mood , mood disorders , hamilton rating scale for depression , physiology , psychology , menstrual cycle , psychiatry , hormone , anxiety , major depressive disorder , economics , macroeconomics
OBJECTIVE Measurements of beta‐arrestin1 in women with premenstrual dysphoric disorder (PMDD) may potentially serve for biochemical diagnostic purposes and might be useful as evidence‐based support for questionnaires. A reduction in beta‐arrestin1 protein in peripheral blood mononuclear leukocytes (PBMC) and associated increased levels of plasma testosterone were demonstrated previously, during depression in women with PMDD. Hyperprolactinemia in patients with mood disorders are well evident. The present study extended our previous work by examining whether disturbances in the prolactin level distinguish in women with PMDD from premenstrual syndrome (PMS). PMDD is a severe form of PMS and as such have been suggested that women with PMDD have greater risk for future depression during pregnancy, post‐partum period and perimenopause. DESIGN METHODS Study participants (n=25) were non‐pregnant women between 18–42 years of age with the symptoms of PMS/PMDD, but not taking any antidepressants and at the luteal phase of menstruation. The protein levels of beta‐arrestin1 in the PBMC were determined by ELISA and the prolactin levels in plasma were measured by radioimmuno assay. The participants were evaluated with Neuropsychiatric Interview (DSMIV‐TR). The severity of depression were determined by the Hamilton Depression Rating Scale scores (HRSD). RESULTS Reduction in beta arrestin1 protein levels in mononuclear leukocytes with the increased levels of plasma prolactin concentrations were significantly correlated in women with depression (PMDD) as compared to PMS women. CONCLUSION These findings support that reduction in beta‐arrestin1 protein in PBMC are significantly correlated with increased levels of plasma prolactin concentrations during depression in women with PMDD. Support or Funding Information Clinical Research Education and Career Development in Minority R25RR17577 (NCRR/NIMHD) and U54 MD007593 (NIMHD) and U54 RR026140 (NCRR) at NIH.