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Skeletal Muscle PPARδ Increases Acutely with Resistance Exercise Inversely Proportional to Body Fat Percentage
Author(s) -
Chen Vincent CW,
Lee Chang Woock,
Bui Steve,
Lee Teak V,
Riechman Steven E
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.lb708
Subject(s) - medicine , endocrinology , skeletal muscle , dyslipidemia , leg press , kinesiology , sports medicine , lipid metabolism , body fat percentage , insulin resistance , resistance training , physical therapy , body mass index , obesity
Purpose PPARδ expression in skeletal muscle has been shown to increase in response to resistance exercise training in our laboratory. However, it is unclear whether PPARδ expression is affected by a single bout of resistance exercise. Since dyslipidemia is associated with excess body fat, we examined the relationship between the change of PPARδ content and percent body fat in response to one bout of whole body resistance exercise. Methods Eleven untrained young men (N=4) and women (N=7) performed one bout of whole body resistance exercise that included leg press and leg extension for emphasis on quadriceps femoris muscles. Body fat percentage was measured by DEXA before exercise. Muscle biopsies were performed on the vastus lateralis muscles 24 hours before and 24 hours after the exercise. Western Blotting was conducted to quantify the PPARδ content. Results With body fat percentage as a covariate, PPARδ levels increased by 49.1% (p<0.001) after one bout of resistance exercise. The amount of changes in PPARδ was inversely proportional to the body fat percentage (R 2 =0.769, P=0.001). Conclusion Our data suggest that when adjusted for body fat percentage, resistance exercise may acutely increase PPARδ content, which may be a key factor of lipid metabolism. Support or Funding Information 1. The Sydney & J.L. Huffines Institute for Sports Medicine & Human Performance 2. American College of Sports Medicine‐ Texas Chapter (TACSM) 3. Department of Health and Kinesiology, Texas A&M University 4. College of Education and Human Development, Texas A&M University