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Beneficial effects of physical exercise under lightening condition on progressive cartilage damage
Author(s) -
Hong Yunkyung,
Jo Youngjin,
Kim Hyunsoo,
Hong Yonggeun
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.lb679
Subject(s) - ex vivo , osteoarthritis , medicine , treadmill , physical exercise , cartilage , physical therapy , pathology , anatomy , biology , in vivo , alternative medicine , microbiology and biotechnology
Osteoarthritis (OA) is frequently occurred in the elderly people. Physical exercise used to be recommended for OA patients, but the effects differ as to how to take exercise. Collagenase‐induced early OA rats were subjected to determine whether environmental light diminishes the beneficial effects of physical exercise on the degenerative musculoskeletal unit. Motor‐driven treadmill exercise (Ex) was applied for 30 min (22:00) on 5 days/week. Intervention was performed for 4 weeks under constant light (LL) as well as 12:12hr light‐dark (L/D). The elevated Mmp13 expression was reduced in the L/D+Ex group, but it was reversed when exercise was executed under LL condition. Exercise under L/D prevented loss of type II collagen (COL2A1) in the cartilage specimens, the effect of which was mitigated in LL condition. Concomitant with these results, the value of joint thickness was recovered in the L/D+Ex group only. Exercise activated autophagic machinery in the periarticular muscle regardless of light condition, the extent of which was higher in the L/D+Ex group than the LL+Ex group. However, CHOP protein was more present in the LL+Ex group. Taken together, musculoskeletal remodeling induced by physical exercise might be affected by lightening condition in vivo animal model. Support or Funding Information NRF‐2012R1A1A2005089, NRF‐2013R1A2A2A01067169, NRF‐2015R1C1A2A01055691