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A role of hemodynamic stress in carotid stenosis; a study using computational fluid dynamic analyses
Author(s) -
Fukuda Shunichi,
Shimogonya Yuji
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.lb649
Subject(s) - stenosis , hemodynamics , medicine , shear stress , cardiology , carotid arteries , radiology , mechanics , physics
Background It is difficult to predict cervical carotid stenosis because our current understanding of its risk factors is incomplete. Several reports suggested that carotid arterial geometry is an independent risk factor for carotid atherosclerotic disease in association with disturbed flow. However, there are few reports indicating a quantitative analysis in hemodynamic distributions of carotid stenosis. Thus, we examined here hemodynamic involvement in carotid stenosis using computational fluid dynamic (CFD) techniques. Methods Distributions of time‐averaged wall shear stress (TAWSS), time‐averaged WSS gradient (TAWSSG), oscillatory shear index (OSI), gradient oscillatory number (GON) proposed by us, and transverse wall shear stress (transWSS) in stenotic (n=11) and non‐stenotic (n=5) cervical carotid arteries were examined using ANSYS‐CFX software. Patient‐specific arterial geometries and inflow velocities were obtained from 3‐dimentional CTA images and carotid ultrasound Doppler examinations. Results TAWSSG in stenotic arteries tended to be higher compared with non‐stenotic arteries (p=0.157). There was a tendency that transWSS and GON, metrics for disturbed flow, were higher in stenotic vessels than non‐stenotic vessels (p=0.112 and 0.234, respectively). Moreover, there were significant increases in TAWSSG and transWSS in severe stenotic arteries (more than 75% in area) compared with non‐stenotic arteries ( Figure 1; p=0.0143 and 0.0274, respectively). Conclusions The data suggest that CFD analyses in distributions of WSS and disturbed flow may serve to clarify new risk factors for carotid stenosis. We are planning multi‐institutional clinical trial about the issue. Support or Funding Information This research was supported by AMED‐CREST, AMED.