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The role of conditional controlled photoperiodicity with propionic acid in induction of autism‐mimetic animal model during prenatal phase
Author(s) -
Lee Seunghoon,
Hong Yonggeun
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.lb640
Subject(s) - hippocampus , fetus , pregnancy , endogeny , prenatal development , melatonin , endocrinology , medicine , secretion , biology , neuroscience , genetics
We determined whether prenatal pups were affected the brain and physiological development by exposure of propionic acid (PPA) as well as conditional photoperiods, which are could be modulate the secretion of endogenous melatonin secretion. Indirectly PPA‐treated rats were significantly increased body weight at 3‐ and 4‐week‐old after partus. All of PPA‐treated rats brain was organized the neuronal cell more than control groups following controlled photoperiodicity. All of experimental groups were not significantly altered organization of neural cells components. In behavioral test, constant dark condition (DD) revealed to delayed organization of neural architecture in cerebral cortex and hippocampus compared to constant light condition (LL). There were not significantly altered an exploring activity. Conversely, PPA+DD was similarly increased an inner square exploring activity but not in the PPA+LL group. We were not clearly defined for autism‐mimetic animal model induction during prenatal period via PPA exposure. Conditional controlled photoperiodicity might act on environmental stress for embryonic neural development in both control and PPA exposure. In future, we will process the embryonic stage for PPA exposure via placenta. Thus, we will clarify the effect of prenatal PPA exposure during pregnancy with conditional photoperiod. Support or Funding Information Funding: NRF‐2012R1A1A2005089, NRF‐2013R1A2A2A01067169