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A Study of the Influence of Single Nucleotide Gene Polymorphisms on the Risk of Hypertension
Author(s) -
Soliman Naglaa Raafat Abdraboh,
Hemimi Neveen Salah
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.lb64
Subject(s) - methylenetetrahydrofolate reductase , single nucleotide polymorphism , enos , medicine , allele , endocrinology , polymorphism (computer science) , genetics , biology , gene , genotype , nitric oxide , nitric oxide synthase
Background Several allele variants of human genes are proved to be linked with parthenogenesis of hypertension. The aim of this study is to identify the association of hypertension with single nucleotide polymorphism in four genes including, endothelial nitric oxide synthase (eNOS rs 1799983), angiotensinogen (AGT rs 699), lipoprotein lipase (LPL rs 320), and methyl tetrahydrofolate reductase (MTHFR rs 180113338, MTHFR rs 1801131 ). Material and Method The SNPs were genotyped in 180 hypertensive and 198 age and gender matched normotensive individuals using polymerase chain reaction‐ restriction fragment length polymorphism. Results eNOS rs 1799983 and AGT rs 699 were found to be significantly associated with hypertension OR (95% CI) 2.7(1.27–5.60); and 2.3 (1.00–5.10) respectively, p<0.05. The other 3 SNPs have shown a tendency to increase the risk with OR between 1.5 and 2.2 with no statistical significance. The risk of hypertension was increased with simultaneous presence of risky alleles of eNOS rs 1799983 with other SNPs as MTHFR rs 1801131 OR 2.2 (0.70–2.69), AGT rs 699 OR 2.6 (0.3–22.99), LPL rs 320 OR 4.2 (1.88–9.41) and rs 180113338 OR 4.8 (1.19–19.27). Conclusion We concluded that coincident appearance of some genetic alleles may increase the risk of hypertension and could be a predictive genetic profile for the disease. Support or Funding Information The research was funded by Dubai Medical College.