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Low‐intensity exercise training improves autonomic modulation and cardiac function in a potential model of Gulf War illness in mice with organophosphate (DFP) exposure: analyze by noninvasive method of cardiovascular measures
Author(s) -
Machi Jacqueline Freire,
Conti Filipe,
Hernandez Diana,
Salgueiro Luis,
Klimas Nancy,
Fletcher Mary Ann,
Morris Mariana
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.lb585
Subject(s) - medicine , isovolumetric contraction , cardiac function curve , cardiology , autonomic function , heart rate , diastole , heart rate variability , diastolic function , isovolumic relaxation time , intensity (physics) , physical therapy , blood pressure , heart failure , physics , quantum mechanics
Background Several conditions and exposures have been hypothesized to serve as instigating events that precipitated the recurring/ chronic symptoms associated with Gulf War illness (GWI). Our group was focused on the use of DFP as chemicals which can be used to produce models of GWI. Purpose The objective in this new study was the determination of the influence of DFP on cardiac (Echo), autonomic (spectral analysis) parameters in association with long term exercise training (6 months). Methods Male mice were divided into (n=8/group): Sedentary (S) and trained (T) groups. The exercise training was performed on an electronic wheel at low intensity for 1 h a day, 5 days/wk for 6 months. We used sc injection of DFP with dose of 1.5 mg/kg after 6 months of exercise program. Heart rate was recorded using the electronic platform provided by the echocardiography machine. The mice were kept under anesthesia (Isoflurane, 2 – 2.5% on 0.8l/min of O2) and positioned on the board with ECG sensors. The cardiac autonomic modulation was evaluated by spectral analysis. Cardiac function was assessed by echocardiography. Results T group showed better diastolic function with lower isovolumetric relaxation time (IVRT) (T: 14.5±0.3 vs S: 17.2±0.8 ms), E wave deceleration time (Desac. E) (T: 30.7±3 vs S: 15±0.91 ms), and cardiac global function by the myocardial performance index MPI (T: 0.29±0.007 vs S: 0.52±0.07). Regard to morphological parameters such as end diastolic diameter (EDD: T: 0.36±0.008 vs S: 0.32±0.008) end systolic diameter (ESD: T: 0.20±0.01 vs S: 0.15±0.01) and Left ventricular mass (LVM: T: 0.17±0.01 vs S: 0.13±0.007) were increased in T group compared to S group. Finally sympathetic modulation (LF) was lower in T groups (T: 24± 3 %) compared to S group (S: 40±4%). Vagal modulation was similar between both groups (T: 18±4 vs S: 30±7 %) as well as LF/HF ratio (T: 2.1±0.4 vs S: 1.5±0.3 beats/min). Conclusion Our findings demonstrated that Low‐intensity exercise training coupled with organophosphate exposure reduced sympathetic modulation and improved cardiac function which could result in an improved quality of life and longevity of this population. Support or Funding Information Award Number: W81XWH‐13‐2‐0085