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Resveratrol‐Enriched Rice Protects Human Skin against UVB‐Induced Photoaging
Author(s) -
Lee Taek Hwan,
Subedi Lalita,
Wahedi Hussain Mustatab,
Park Yong Un,
Kim Sun Yeou
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.lb557
Subject(s) - photoaging , wrinkle , resveratrol , human skin , skin aging , matrix metalloproteinase , chemistry , dermatology , antioxidant , pharmacology , medicine , biochemistry , biology , genetics , gerontology
Ultraviolent radiation can cause skin photoaging, skin wrinkle and pigmentations. Synthetic cosmaceuticals as well as medicines have number of side effects as well as drawbacks so natural therapies are the best way of protecting human skin and looking young and smart. Genetically engineered Resveratrol‐enriched rice (RR) has been reported to have excellent anti‐obesity and depigmenting effects in human skin however its effect in UVB induced skin aging was not studied yet. In this study, we evaluated the effects of normal rice (NR), resveratrol‐enriched rice (RR), and resveratrol (R) on ultraviolet B (UVB)‐irradiated human dermal fibroblasts (HDFs) and reconstructed skin tissue to determine the therapeutic potential of these agents in skin wrinkling and skin photoaging. We measured the cellular levels of procollagen type I (PIP‐1) and matrix metalloproteinase (MMP)‐1 using ELISA in NHDF cells after UVB irradiation. UVB‐irradiated NHDF cells that were treated with NR, RR, and R exhibited higher PIP‐1 levels and lower MMP‐1 levels than untreated cells. Among the treatments, RR was found to have the maximum potential to prevent skin damage in both, for MMP‐1 inhibition as well as PIP induction. Taken together, our findings demonstrated that the anti‐wrinkle properties of RR might be superior to those of R or NR alone. Additionally, RR possesses anti‐skin photoaging effects, via downregulating the MMP‐1 levels and upregulating the pro‐collagen production in UVB‐irradiated reconstructed skin as well. In conclusion, RR may provide a non‐toxic and convenient means of preventing UVB‐induced skin wrinkles and related diseases. Support or Funding Information This work was supported by a grant from the Next‐Generation BioGreen 21 Program (No. PJ01118803), Rural Development Administration, Republic of Korea