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Effects of Artemisia Annua leaf extract on hepatic steatosis and inflammation in high‐fat diet‐fed mice
Author(s) -
Jeong Eun Ae,
Kim Kyung Eun,
Yi Chinok,
Lee Jong Youl,
Roh Gu Seob
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.lb449
Subject(s) - steatosis , medicine , insulin resistance , endocrinology , artemisia annua , inflammation , ctgf , western blot , chemistry , biology , diabetes mellitus , growth factor , immunology , biochemistry , artemisinin , receptor , malaria , gene , plasmodium falciparum
Artemisia Annua L. (AA) is a well‐known source of the antimalarial drug artemisinin. AA also has an antibacterial and antioxidant activity. However, the effect of AA extract on hepatic steatosis induced by obesity is unclear. We investigated whether AA extract prevents obesity‐induced insulin resistance and hepatic steatosis in high‐fat diet (HFD)‐fed mice. Mice were randomly divided into groups that received a normal chow diet (ND) and HFD with or without AA for 12 weeks. We found that AA extract reduced insulin resistance and hepatic steatosis in HFD‐fed mice. Western blot analysis showed that HFD‐induced expression of nuclear sterol regulatory element‐binding protein 1 (SREBP1) and carbohydrate response element‐binding protein (ChREBP) in the livers was decreased by AA extract. In particular, dietary administration of AA extract decreased hepatic high‐mobility group box 1 (HMGB1) and cyclooxygenase‐2 (COX‐2) expression in HFD‐fed mice. AA extract also attenuated HFD‐induced collagen deposition and fibrosis‐related transforming growth factor (TGF)‐β1 and connective tissue growth factor (CTGF). These data indicate that dietary AA extract has beneficial effects on hepatic steatosis and inflammation in HFD‐fed mice. Support or Funding Information National Research Foundation of Korea (No.2014R1A2A1A11049588)