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Relationship of blood levels of homocysteine, folate and vitamin B12 with dietary nutrient density in Korean middle‐aged women with type 2 diabetes
Author(s) -
Kim Eunkyung,
Kim Hyesook,
Oh Ji Soo,
Choi Young Ju,
Huh Kap Bum,
Chang Namsoo
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.lb428
Subject(s) - homocysteine , vitamin b12 , medicine , diabetes mellitus , physiology , type 2 diabetes , endocrinology , nutrient , b vitamins , biology , ecology
This study was conducted to examine the association between blood levels of homocysteine, folate, and vitamin B12 and nutrient density (nutrient content/1000kcal) in diet among middle‐aged women with type 2 diabetes (n=162, mean age=57.6±4.0 years). Dietary intake was assessed by semiquantitative food frequency questionnaire method. Multiple regression analysis showed that blood homocysteine concentration was positively correlated with dietary fat (p=0.0466) and negatively correlated with dietary fiber (p=0.0078) after adjusting for age, BMI, occupation, education, smoking and alcohol intake. Blood folate was positively correlated with dietary folate (p=0.0478). Blood homocysteine was negatively correlated with blood folate (p=0.0092) and vitamin B12 (p=0.0002), and a positive correlation (p=0.0228) was observed between blood folate and vitamin B12. Previous studies have reported on the association between levels of blood homocysteine and elastic properties of the arterial wall where high levels of blood homocysteine increases CVD risk. Through explaining the relationship between dietary fiber and folate and levels of blood homocysteine and folate, this study further proves an inverse relationship between consumption of foods rich in fiber and folate and CVD risk. Support or Funding Information [This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF‐2013R1A1A2011544) and Brain Korea 21 Plus.]