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Relation between serum 25 hydroxyvitamin D concentrations and metabolic syndrome and diabetes mellitus
Author(s) -
Ganji Vijay,
Zhang Xu
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.lb371
Subject(s) - medicine , endocrinology , metabolic syndrome , diabetes mellitus , vitamin d and neurology , waist , national health and nutrition examination survey , vitamin d deficiency , obesity , population , environmental health
Objective A relation between serum 25 hydroxyvitamin D [25(OH)D] concentrations and prevalence of metabolic syndrome (MetS), diabetes mellitus (DM), and several cardiometabolic risk factors in >19 years old persons using quality control‐adjusted data from three cycles of National Health and Nutrition Examination Survey (NHANES), 2001–2006 (n=8241) was investigated. Results Persons with serum 25(OH)D concentration <30 nmol/L had significantly higher waist circumference ( P <0.001), blood glucose ( P <0.001), glycohemoglobin ( P <0.001), triglycerides ( P <0.001), insulin ( P <0.001), C‐peptide ( P <0.001), C‐reactive protein, and HOMA‐IR ( P =0.001) and had significantly lower HDL‐cholesterol and VO 2 max ( P <0.001) compared to those with serum 25(OH)D concentration ≥75 nmol/L. Prevalence of MetS and DM were significantly higher in persons with serum 25(OH)D concentration <30 nmol/L compared to those with serum 25(OH)D concentration ≥75 nmol/L (P<0.001). The likelihood of having MetS ( OR , 2.9; CI , 2.1, 4.0; P<0.001) and DM ( OR , 1.7; CI , 1.2, 2.4; P <0.001) were significantly higher in serum 25(OH)D concentration <30 nmol/L group compared to serum 25(OH)D concentration ≥75 nmol/L group. Conclusion Because improved vitamin D status is associated with positive health outcomes, consideration should be given to raising serum vitamin D concentration ≥75 nmol/L in reducing the risk of chronic diseases. Support or Funding Information Supported by Life University and University of Mississippi Medical Center