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Anti‐aging and redox state regulation effects of type‐A proanthocyanidins‐rich cranberry concentrate and its comparison with grape seed extract in mice
Author(s) -
Jiao Jingjing,
Wei Yan,
Zhang Yu
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.lb355
Subject(s) - grape seed extract , tbars , chemistry , antioxidant , superoxide dismutase , glutathione peroxidase , biochemistry , glutathione , oxidative stress , proanthocyanidin , catalase , redox , pharmacology , biology , lipid peroxidation , medicine , enzyme , polyphenol , pathology , alternative medicine , organic chemistry
In current study, we investigated whether type‐A proanthocyanidins (PACs)‐rich cranberry concentrate (CBC) exerts anti‐aging and redox state regulation effects and compared with the effects of type‐B PACs‐rich grape seed extract (GSE). Using the D‐galactose‐induced aging mice model, effects of both CBC and GSE were investigated via an 8‐week oral gavage administration considering vitamin E as the positive control. Results showed that both CBC and GSE reduce hepatic and brain thiobarbituric acid reactive substances (TBARS), presented as malonaldehyde (MDA) equivalents, and plasma 8‐isoprostane levels by 30%–57%, 24%–30% and 11%–62%, respectively, and decrease brain and plasma monoamine oxidase (MAO) activities by 27%–59% and 65%–71%, respectively. CBC is capable of improving hepatic glutathione peroxidase (GSH‐Px) activities by 42%, while GSE is able to enhance hepatic superoxide dismutase (SOD) activities by 13%. Therefore, CBC/GSE exerts anti‐aging effects probably via regulating in vivo redox state. Type‐A linked PACs regulate GSH‐Px activities while type‐B PACs mainly improve SOD activities, while neither generates any effect on catalase (CAT) activities. These findings provide pioneer in vivo evidence that type‐A PACs‐rich CBC has distinguished potential in aspects of anti‐aging and redox state regulation compared with well‐known type‐B PACs‐rich GSE, which deserve to be further concerned. Support or Funding Information National Natural Science Foundation of China (31201307)