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Anti‐adipogenic effects of various traditional bioresources in Korea during the differentiation of 3T3‐L1 preadipocytes
Author(s) -
CHOI SUNIL,
Lee Jong Seok,
Lee Sarah,
Oh JiWon,
Kim JaeMin,
Jung TaeDong,
Shin GiHae,
Lee JinHa,
Cho MyoungLae,
Yang HeeSun,
Yeo Joohong,
Kim JongYae,
Lee OkHwan
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.lb337
Subject(s) - adipogenesis , oil red o , chemistry , downregulation and upregulation , abts , reactive oxygen species , biochemistry , food science , antioxidant , in vitro , gene , dpph
The aim of this study was to investigate the anti‐oxidant and anti‐adipogenic effects of various traditional bioresources. The results revealed that Castanea crenata Siebold & Zucc. showed the higher total flavonoids content (47.90±0.92 mg QE/g) and ABTS radical scavenging activity (28.15±1.16 IC 50 ) than those of other traditional bioresources. Furthermore, Cornus officinalis Siebold & Zucc. showed the higher than those of other traditional bioresources in reducing power (0.74±0.04). All of the traditional bioresources markedly reduced lipid accumulation and reactive oxygen species (ROS) production in 3T3‐L1 cells. It was investigated by Oil red O staining and NBT assay. In addition, traditional bioresources inhibited the expression levels of adipogenic transcription factors such as a PPAR‐γ and C/EBP‐a. These results indicate that traditional bioresources exerts the anti‐oxidant and anti‐adipogenic effects through a mechanism(s) that may involve downregulation of adipogenesis.