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Evaluation of an Insulin Sensitivity Index from the Short Intravenous Glucose Tolerance Test for Detecting Response to a Dietary Intervention
Author(s) -
Maki Kevin C,
Nieman Kristin M,
Cook Chad M,
Huebner Margie,
Baum Seth J
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.lb288
Subject(s) - insulin , medicine , interquartile range , crossover study , insulin sensitivity , endocrinology , bolus (digestion) , insulin response , zoology , insulin resistance , chemistry , plasma glucose , placebo , biology , alternative medicine , pathology
The aim of this analysis was to evaluate an insulin sensitivity index (Tura SI) from the short (50 min) insulin‐modified intravenous glucose tolerance test (IVGTT), compared with minimal model analysis of 180 min IVGTT data (MM SI). Subjects, a subset of a clinical trial sample ( J Nutr 2012;142:717–723) who agreed to take part in a substudy, included men (n = 8) and women (n = 16), with mean (SD) age 48.9 (9.9) y and body mass index 30.8 (4.9) kg/m 2 . Participants consumed 0, 15, and 30 g/d high‐amylose resistant starch (RS) for 4 wk each in a double‐blind, randomized, crossover trial. MM SI was assessed after each condition with a 0.3 g/kg IV glucose bolus (t = 0 min) followed by regular human insulin (0.03 U/kg, t = 20 min). Plasma samples were collected at frequent intervals over 180 min. MM SI was calculated with MINMOD MILLENIUM v6.02. Tura SI was calculated as the fractional glucose disappearance rate/mean increment above baseline plasma insulin, both from 10–50 min. MM SI and Tura SI were 3.70 (2.85) and 3.24 (2.17) × 10 −4 L/(min*mU), respectively. Median (interquartile limits) % changes from control at 15 g/d RS were 28.3 (−2.7, 85.3; p = 0.005) and 29.2 (−8.3, 74.4; p = 0.01), for MM SI and Tura SI, respectively; 30 g/d RS values were 16.1 (−9.8, 58.9; p = 0.03), and 19.3 (−12.8, 47.6; p = 0.03), for MM SI and Tura SI, respectively. The two indices were highly correlated during each condition: r = 0.957 (control), 0.920 (15 g/d), and 0.958 (30 g/d) (all p <0.001). These results support the use of Tura SI as a less costly and time‐consuming method than MM SI for assessing changes in whole‐body insulin sensitivity. Support or Funding Information Ingredion, Westchester, IL