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Long‐term Weight and Metabolic Effects of Olanzapine in Mice and the Impacts of Fish Oil Supplementation
Author(s) -
Stewart Brandon,
Ramalingam Latha,
Menikdewella Kalhara,
MoustaidMoussa Naima,
Soto Paul
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.lb265
Subject(s) - olanzapine , fish oil , endocrinology , medicine , insulin resistance , obesity , adipose tissue , weight gain , type 2 diabetes , lean body mass , diabetes mellitus , insulin , chemistry , biology , body weight , fish <actinopterygii> , schizophrenia (object oriented programming) , psychiatry , fishery
Antipsychotic medications have been associated with rapid weight gain and metabolic dysfunction, which may lead to increased risk for heart disease, diabetes, obesity, and many other serious, life threatening illnesses. Prescribing antipsychotics has increased in adolescents and children; the most common medication being olanzapine (OLZ). The current study investigated the long‐term effects of early‐life exposure to olanzapine in mice, and the impact of a fish oil supplementation. Male C57BL/6J mice were administered cookie dough containing OLZ, or just plain cookie dough, daily from postnatal day 37 to 65, and maintained on one of two diets, a high‐fat (HF)‐high sugar (HS) diet or a HF‐HS diet supplemented with fish oil (FO), resulting in four groups of mice (n=8): HF‐HS, HF‐HS+OLZ, HF‐HS‐FO, HF‐HS‐FO+OLZ. Body weights and food consumed were measured daily. Glucose and insulin tolerance, and fat composition were measured post‐drug treatment. Body weights and fat mass were highest in the HF‐HS group, and equivalent among the remaining three groups despite the lack of any significant difference in amounts of food consumption in all four groups. The HF‐HS group exhibited the lowest clearance rate of glucose and the highest insulin resistance. Analysis of gene expression and inflammatory cytokines in adipose tissue may provide insight as to the mechanisms underlying the long‐term effects of OLZ. These data suggest that early‐life exposure to OLZ may produce sustaining alterations in metabolic function and body mass composition. Support or Funding Information TTU Presidential Cluster Hire Tier 2 and Obesity Research Cluster Pilot & Feasibility award