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Serum vitamin D as a potential nutritional biomarker relating to the risk of schizophrenia
Author(s) -
Yang Soo Jin,
Lim So Young,
Kim SungWan
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.lb259
Subject(s) - schizophrenia (object oriented programming) , medicine , biomarker , vitamin , vitamin d and neurology , physiology , metabolic syndrome , triglyceride , vitamin e , cholesterol , endocrinology , biology , psychiatry , obesity , antioxidant , biochemistry
Nutrient and physiological imbalance is associated with the development of schizophrenia. One noticeable phenotype of subjects with schizophrenia is the increased prevalence of metabolic syndrome. Its underlying mechanisms have not yet clearly identified; however, medications and unhealthy lifestyle choices including physical inactivity and unbalanced diet may be contributing factors for developing metabolic syndrome. In this study, we investigated whether dietary factors and blood nutritional biomarkers are associated with the prevalence of schizophrenia in Korean adults. Forty seven subjects with schizophrenia were voluntarily participated and age/sex‐matched controls were utilized as controls. Dietary habits and intakes from foods were assessed with modified questionnaires for dietary guideline adherence score and semi‐quantitative food frequency questionnaires. Dietary intakes of energy and nutrients were estimated using a computer software program based on the standard tables of food composition. Also, nutritional biomarkers were analyzed in serum samples. Dietary intakes of cholesterol, vitamin D, and sodium were higher in subjects with schizophrenia compared with controls. Decreased levels of HDL cholesterol and vitamin D and increased concentrations of serum triglyceride and higher activities of AST and ALT were shown in serum samples from schizophrenic subjects compared with controls. These serum data suggest that schizophrenic subjects are at higher risk of developing metabolic syndrome and they may have higher metabolic turnover of vitamin D, which suggests that vitamin D needs to be considered as potential nutritional biomarker of the risk of schizophrenia.