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Effect of Hovenia dulcis fruit extract on alcohol‐induced metabolism, inflammation and hangover following acute alcohol consumption: A randomized, double‐blind, placebo‐controlled study
Author(s) -
Kim Hoe Jin,
Park Min Young,
Lee Yu Jin,
Kim Joo Hee,
Kim Ji Yeon,
Kwon Oran
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.lb209
Subject(s) - acetaldehyde , alcohol , placebo , ethanol , liver injury , ethanol metabolism , chemistry , medicine , pharmacology , biochemistry , pathology , alternative medicine
Hovenia dulcis ( H. dulcis ) has been used as a food supplement and traditional herbal medicine for the treatment of liver injury and alcohol toxicity. Hepatoprotective and antioxidative effect were investigated in vitro and mice, but not in human yet. Therefore, the present study aimed to examine the effect of H. dulcis fruit extract on alcohol metabolism and hangover symptoms as well as alcohol‐induced inflammation in human. We performed a randomized double‐blind crossover trial in 26 healthy young men with ALDH2*1/2 genotype, who has low ability to change acetaldehyde to acetate. At each visit, all subjects consumed 50g alcohol after 30 min from placebo or H. dulcis treatment. We collected blood samples 5 times until 12h after alcohol consumption. Serum alcohol level, acetaldehyde level, and expiratory alcohol level were used as markers for alcohol metabolism. Lipopolysaccharide (LPS), Lipopolysaccharide‐binding protein (LBP), soluble CD14 (sCD14) were used as markers for alcohol‐induced inflammation. Aspartate aminotransferase (AST), alanine aminotransferase (ALT) were used as markers for hepatocyte damage. Hangover questionnaire was used to assess the hangover severity. Serum alcohol, acetaldehyde level and expiratory alcohol level showed no difference between placebo and H. dulcis groups, indicating that H. dulcis does not have an effect on the metabolism of alcohol. LPS and sCD14 were also no difference between groups. However, LBP was higher within H. dulcis group at 12 hour (p<0.05). While the total of hangover questionnaire score had no statistical difference, the hangover severity after peak time was significantly lower within H. dulcis group (p<0.05; especially headache, dizziness, and weakness.) ALT was significantly improved by H. dulcis (p<0.05). In conclusion, acute alcohol consumption does not seem to cause dysfunction of intestine permeability lead to endotoxemia and H. dulcis fruit extract may have potential to improve hangover symptoms and alcohol‐induced hepatic damage. Support or Funding Information This work was supported by the Ministry of Science, ICT & Future Planning (Bio‐synergy Research Project NRF2012M3A9C4048761) and BK21 PLUS through the National Research Foundation.