Premium
New Theory of Holistic Integrative Physiology and Medicine I: Structural Frame of Life Control
Author(s) -
Sun XingGuo
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.986.7
Subject(s) - breathing , neuroscience , biology , physiology , chemistry , anatomy , medicine
Objective The modern systemic physiology, based on each functional system alone, has significant limitations. Human being is an organic set of all functions. We plan to discuss the life control involving all systems. Methods We did establish the raw functional structure of new theory to explain the control and regulation of life. Results After birth, independent human being's life is depended upon two core functional axis. The first one is respiration‐circulation‐metabolism, and the second one is digestion and absorption‐circulation‐metabolism. The main function of them is to maintain the homeostasis for cells’ metabolic activities in the body. The first functional axis is dominantly to keep balance between supply and demand of gases (O2, and CO2 etc.). The second is to keep balance between supply and demand of materials (glucose, fatty acid, amino acid and lactic etc.) in the body. Use circulation as a central coupling, we constructed a main control circles for life. The circulation‐metabolism is shared parts by both axis. After birth, we start our independent life. Traditionally, breathing is the only vital sign, so that we focused on the breathing control (be discussed in others abstracts) linking with all others. The structural frame of life control The cortex is the mind over control for almost functions. Under cortex, main breathing control circle consists of peripheral chemical/pressure receptors in arterial line (aorta arch and carotid body), afferent nerves, central integrative center (medulla and central chemical receptor), efferent nerves, N‐M connection, muscles (alternative constriction and relaxation), diaphragm and chest wall, lung and airway, pulmonary capillary, pulmonary vein, left atrium, left ventricle, and artery. The signal from receptors to muscles is transferred electronically, which dominantly neuron‐control; but signal from lung to receptors at artery is transferred by blood flow, which dominantly heart‐control. The secondary circle of breathing control is the circulation. It consists of artery, capillary (all cells metabolic activities: resting, exercise and sleeping. GI uptake, liver metabolism and kidney elimination), vein, right atrium, right ventricle, pulmonary artery, pulmonary capillary, pulmonary vein, left atrium, left ventricle, and artery. The pulmonary capillary, pulmonary vein, left atrium, left ventricle, and artery are the shared parts in both main and side circles. And the autonomic (sympathetic and parasympathetic) nerves, from central integrative center, control the heart and blood vessel for circulatory regulation. Conclusion We can explain that the life control through the integration of all functions of respiration, circulation, nerve, digestion, absorption and elimination, metabolism, exercise, sleeping, etc. together. Support or Funding Information CNSF‐Medical Science Program (81470204); NCCVD Fuwai Hospital Start Program (2012‐YJR02)