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Function of the Ang II system during the ontogeny of Archosaurs
Author(s) -
Crossley Dane Alan,
Eme John,
Tate Kevin,
Mueller Casey
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.976.5
Subject(s) - medicine , endocrinology , biology , baroreflex , ontogeny , angiotensin ii , alligator , extant taxon , receptor , blood pressure , embryogenesis , agonist , renin–angiotensin system , microbiology and biotechnology , embryo , heart rate , evolutionary biology , paleontology
Development of cardiovascular regulation in embryonic birds and reptiles has become an area of growing interest over the past 20 yrs. Embryonic cardiovascular control is predominantly dependent on humoral mechanisms across these vertebrate groups. This is evident in the absence of autonomic tone in many species of birds and reptiles, as well as elevated levels of circulating catecholamines. In addition to circulating catecholamines, other humoral regulators have been identified to contribute to baseline regulation of the embryonic cardiovascular system, including angiotensin II (Ang II). Initial work has illustrated that in two representative, extant archosaurs, the domestic chicken ( Gallus domesticus ) and the American alligator, Ang II produces a dose dependent increase in arterial pressure that is mediated, in part by alpha‐adrenergic receptor stimulation. While the agonist produced a clear cardiovascular response in these species, the response is unaltered by known Ang II receptor antagonists. Direct inhibition was unsuccessful, but indirect manipulation of the Ang II system by decreasing angiotensin converting enzyme function produced noted reductions in arterial pressure, altered organ system size, and altered baroreflex function. This suggests Ang II is an important tonic regulator of cardiovascular function in Archosaurs during development. Support or Funding Information NSF CAREER award IBN IOS‐0845741 to Dane A Crossley II