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From Protein Folding to Cognition: The Serendipitous Path of Discovery
Author(s) -
Walter Peter
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.97.1
Subject(s) - enhancer , phosphorylation , drug discovery , cognition , folding (dsp implementation) , neuroscience , small molecule , protein folding , computational biology , microbiology and biotechnology , biology , chemistry , bioinformatics , biochemistry , gene , gene expression , engineering , electrical engineering
A screen for small molecule modulators of the unfolded protein response yielded ISRIB, a drug‐like compound that with high efficacy renders cells insensitive to translational inhibition by phosphorylation of eIF2. ISRIB proved to be a cognitive enhancer in rodents, significantly improving long‐term memory of wild‐type animals in behavioral assays.