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1,2,3,4,6‐penta–O‐galloyl–β–D–glucose ameliorates renal injury in ischemia‐reperfusion induced acute renal failure rats
Author(s) -
Park Ji Hun,
Lee Yun Jung,
Kim Hye Yoom,
Yoon Jung Joo,
Kho Min Chol,
Lee So Heun,
Lee Han Sol,
Jin Xian Jun,
Lee Ho Sub,
Kang Dae Gill
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.967.26
Subject(s) - renal function , medicine , kidney , creatinine , renal ischemia , ischemia , endocrinology , blood urea nitrogen , acute kidney injury , inflammation , reperfusion injury , urology , pharmacology
Renal ischemia‐reperfusion (I/R) injury, an important cause of acute renal failure, cause decreased glomerular filtration rate and kidney microvascular inflammation. 1,2,3,4,6‐penta–O‐galloyl–β–D–glucose (PGG) has anti‐cancer, anti‐oxidation and angiogenesis effects. We examined protective effects of PGG on I/R‐induced acute renal failure rats. Ischemia was induced by clamping the both renal arteries during 45 min followed by reperfusion. Peritoneal injection of 10, 50 mg/kg/day PGG to ischemia‐reperfusion rat and I/R injury was measured after 2 or 4 days respectively following PGG treatment. Treatment with PGG significantly ameliorates urine volume, urine osmolality, creatinine clearance (Ccr) and blood urea nitrogen (BUN). In addition, PGG increases aquaporine 1/2/3 and Na + ‐K + ‐ATPase and decreases ICAM‐1, MCP‐1, and HMGB‐1 expression. In histopathologic study, PGG improved glomerular and tubular damage. Immunohistochemistry results showed that PGG increased aquaporine 1/2, and Na + ‐K + ‐ATPase whereas decreased ICAM‐1 expression. These findings suggest that PGG ameliorates renal injury including renal function and microvascular inflammation in I/R‐ induced acute renal failure rats.