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Overweight was related with sympathetic activation in offspring of hypertensives
Author(s) -
Viana Ariane Oliveira,
Rosa Fernando Alves Santa,
Nascimento Mario Cesar,
Shimojo Guilherme Lemos,
De Paiva Júlia,
De Angelis Kátia
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.959.10
Subject(s) - overweight , medicine , blood pressure , diastole , cardiology , body mass index , obesity , heart rate , anthropometry , hemodynamics , endocrinology
Hypertension is a clinical condition with high rates of cardiac events and mortality. This disease has been related to overweight/obesity, cardiovascular and autonomic dysfunctions. The objective of this study was to evaluate anthropometric, hemodynamic and autonomic parameters in sedentary men with a positive (HS n= 32) or negative (NS n= 30) familial history of hypertension. A cross‐sectional study was performed with 62 healthy sedentary men (20–48 years old). The body mass index (BMI) was calculated and the blood pressure (BP) was measured 3 times by the auscultatory method. The RR interval was recording during a 20 minute period at rest using a frequencimeter (Polar® RS800 model). The heart rate variability was evaluated in the time and frequency domain. The overweight subjects (n=45, BMI: 29.22 [IQ 26.96–30.87Kg/m 2 ]) presented significantly higher systolic BP (116.66 [IQ 88–128mmHg] vs. 104 [IQ 76.33–118.33mmHg]) and diastolic BP (85.33 [IQ 80.83–93.94mmHg] vs. 82.88 [IQ 73.00–86.22mmHg]) as compared to the eutrophic group (n= 17, BMI: 24.30 [IQ 24.78–29.72Kg/m 2 ]). In addition, positive correlations were observed between the sympathovagal balance with the systolic BP (r = 0.377, p = 0.011) and the mean BP (r = 0.406, p = 0.006). The BMI was also correlated with diastolic BP (r = 0.335, p = 0.025). Regarding the familial history of hypertension, we observed increased BP and sympathetic modulation in the HS group compared to the NS group. Moreover, BP was increased in overweight HS subjects as compared to overweight NS. Correlation analysis involving HS and NS groups, showed positive correlations between sympathovagal balance with mean BP (r = 0.257, p = 0.044) and systolic BP (r = 0.262, p = 0.039); BMI with diastolic BP (r = 0.389, p = 0.002) and systolic BP (r = 0.336, p = 0.008). In conclusion, the overweight was related with sympathetic activation and BP increase in general populations as well as in offspring of hypertensives. Support or Funding Information Cnpq, Capes, UNINOVE