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Divergent response of circulating CTRP3 levels to obesity between males and females
Author(s) -
Peterson Jonathan M.,
Wagner Roy Marshall,
Sivagnanam Kamesh,
Clark William Andrew
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.956.4
Subject(s) - adipokine , medicine , diabetes mellitus , obesity , body mass index , population , adipose tissue , endocrinology , physiology , insulin resistance , environmental health
C1q TNF alpha related Protein 3 (CTRP3) is a novel adipose tissue derived secreted factor, or adipokine. CTRP3 has been linked to a number of beneficial biological effects on metabolism, inflammation, and survival signaling in a variety of tissues. However, very little is known about CTRP3 in regards to human health. The purpose of this project was to examine circulating CTRP3 levels in a clinical population. It was hypothesized that serum CTRP3 levels would be decreased with obesity and diabetes. Methods body mass index (BMI), diabetes status, and plasma samples were collected from 100 patients who were >30 years of age and presented at the East Tennessee State University Heart Clinic with symptoms requiring heart catheterization in order to identify the presence of cardiovascular blockages (n=51 male, n=49 female). Circulating CTRP3 levels were quantified using commercially available ELISA. Results Circulating concentrations of CTRP3 were significantly higher in normal weight (BMI <30) females (1.65 ± 0.24 μg/ml) compared with males (1.05 ± 0.12 μg/ml). Interestingly obesity (BMI >30) resulted in an increase in circulating CTRP3 levels in male subjects (1.52 ± 0.16 ug/ml) but showed a significant decrease in female subjects (1.11 ± 0.15 μg/ml). Additionally, there was a significant reduction in circulating CTRP3 levels in female subjects who were diagnosed with diabetes compared with patients without diabetes (1.50 ± 0.12 vs. 0.812 ± 0.10 μg/ml). There was no relationship between diabetes status and circulating CTRP3 levels in male subjects. Conclusion Circulating CTRP3 levels had a different relationship with diabetes and obesity status between male and female patients. It is possible that circulating CTRP3 levels are controlled by hormonal status, however more research is needed to explore this relationship. Support or Funding Information College of Clinical and Rehabilitative Health Sciences, East Tennessee State University, Dean's Student Research Award