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Acute effects of dietary nitrate supplementation on peripheral and central blood pressure in post‐menopausal women
Author(s) -
Kim Danielle JinKwang,
Barrett Megan A,
Moore David J,
Flanagan Michael P,
Roe Carly,
KimShapiro Daniel B,
Proctor David N
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.955.5
Subject(s) - supine position , medicine , blood pressure , mean arterial pressure , crossover study , pulse wave velocity , placebo , cardiology , physiology , heart rate , alternative medicine , pathology
Dietary nitrate supplementation (in the form of beetroot juice) has been shown to have multiple cardiovascular health benefits, including both acute and chronic reductions in resting arterial blood pressure. The purpose of this study was to examine the effects of acute dietary nitrate supplementation on peripheral and central blood pressures in postmenopausal women, a population that exhibits accelerated vascular aging and cardiovascular disease progression. We hypothesized that 1) postmenopausal women would have higher resting central blood pressure compared to premenopausal women, and 2) acute dietary nitrate supplementation would reduce resting peripheral and central blood pressure in postmenopausal women. Eighteen women participated in this study (9 premenopausal women, 20–30 yrs; 9 postmenopausal women, 55–70 yrs). Supine peripheral blood pressure (Omron) and radial pulse wave derived central aortic pressure (SphygmoCor CvM, AtCor Medical) were measured after 10 minutes of quiet supine rest. A subset of the postmenopausal women also participated in a randomized double‐blind crossover study during which they consumed beetroot juice (BRJ; 140 mL Beet‐It Sport, James White Juice Company) or placebo (PLC; 140 mL nitrate‐depleted Beet‐It Sport, James White Juice Company) approximately 1 week apart. Supine peripheral and central blood pressures were measured prior to and 90 minutes following juice consumption. Results Postmenopausal women had significantly higher brachial and central blood pressures (systolic, diastolic, and mean), and augmentation index (AI) compared to premenopausal women (all p < 0.05). Acute nitrate supplementation resulted in greater reductions (p<0.05) in brachial mean arterial pressure, central mean arterial pressure, and central systolic blood pressure compared to those observed during the placebo visit. These findings suggest that acute dietary nitrate supplementation favorably modifies resting peripheral and central blood pressures in postmenopausal women. Support or Funding Information Penn State Ambulatory Research Fund (JAFFE Endowment)