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Cardiovascular Implications of Environmental Stressors, a Health Call to Protect the Planet
Author(s) -
Cabrales Pedro,
William Alexander
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.954.2
Subject(s) - nitric oxide , stressor , medicine , environmental chemistry , environmental science , chemistry , clinical psychology
A class of air pollutants known as atmospheric ligands (oxygen, O 2 ; carbon monoxide, CO; nitric oxide, NO; and hydrogen sulfide, H2S) are associated to a variety of physiological process. At atmospheric concentrations below regulatory limits, these atmospheric ligands can be physiologically active. Previous studies have examined their implication on cardiovascular health outcomes at concentrations above US Environmental Protection Agency (EPA) limits. Our studies have focused on cardiovascular effects these gases within good to moderate EPA limits. Hamsters instrumented with dorsal window chambers, or with a miniaturized left ventricle pressure volume (LVPV) were used to study microvascular and systemic implications of acute and chronic exposure to these gases. Our results present the implications of atmosferic polutans on cardiovascular function. Due to the direct implications on health, humanizing the protection of the planet will emphasize the gravity of environmental preservation. Support or Funding Information P01‐HL110900, R01‐HL52684, and R56‐HL123015.