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Radiofrequency Renal Denervation Improves Left Ventricular Function and Hemodynamics Through Modulation of Natriuretic Plasma Peptides in the Setting of Heart Failure
Author(s) -
Polhemus David J,
Gao Juan,
Scarborough Amy,
Trivedi Rishi,
Bradley Jessica,
Goodchild Traci,
Smart Frank,
Kapusta Daniel R,
Lefer David
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.939.4
Subject(s) - medicine , cardiology , ejection fraction , heart failure , atrial natriuretic peptide , natriuretic peptide , stroke volume , brain natriuretic peptide , cardiac function curve , ligation , endocrinology
Background Overactivity of the sympathetic nervous system plays a critical role in the pathogenesis of heart failure. We investigated the effects of renal sympathetic nerve denervation (RDN) on left ventricular (LV) function and vasoactive natriuretic peptide levels in a rodent model of ischemic heart failure. Methods Spontaneously hypertensive rats (SHR) were subjected to 45 min of coronary artery ligation and reperfusion for 12 weeks. At 4 weeks post‐reperfusion, SHR underwent either bilateral radiofrequency RDN (n=9) or sham RDN (n=8) procedure. Every 2 weeks, transthoracic echocardiogram was performed using Vevo 2100 (Visualsonics). LV function was analyzed from EKV™ (ECG‐Gated Kilohertz Visualization) generated M‐mode long‐axis images. 12 weeks following reperfusion, plasma brain natriuretic peptide‐32 (BNP) and atrial natriuretic peptide (ANP) were quantified using ELISA technique. Results RDN preserved LV ejection fraction (49.4 ± 2.6 vs. 32.1 ± 2.6%, p < 0.05) and LV stroke volume (318 ± 24.5 vs. 215 ± 17.8 μl, p < 0.05) at 12 weeks compared to sham. Heart weight/tibia length was also markedly reduced in the RDN group (41 ± 2.4 vs. 49 ± 1.2 mg/mm, p < 0.05). Despite reduced cardiac enlargement, Plasma BNP levels (377.7 ± 12.0 vs. 166.6 ± 37.3 pg/ml, p < 0.05) and ANP levels (297.0 ± 25.7 vs. 57.0 ± 12.4, p < 0.05) were significantly elevated in the RDN treated group compared to sham. Conclusion Radiofrequency RDN improved LV function, reduced remodeling and significantly increased circulating cardioprotective natriuretic peptides. We conclude that RDN exerts beneficial effects in preventing and treating heart failure following coronary ischemia and reperfusion; in part via increasing circulating cardiprotective natriuretic peptides. Support or Funding Information P30GM106392 to DK