Premium
Subacute toxicity of cadmium sulfide quantum dots coated with maltodextrin in vivo
Author(s) -
GutiérrezSancha Ivonne,
ReyesEsparza Jorge,
RodríguezFragoso Patricia,
RodriguezFragoso Lourdes
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.933.7
Subject(s) - toxicity , cadmium sulfide , quantum dot , fluorescence , kidney , in vivo , chemistry , beagle , cadmium , pathology , medicine , nanotechnology , materials science , biology , inorganic chemistry , physics , microbiology and biotechnology , quantum mechanics , organic chemistry
In this study, we evaluated the subacute toxicity of cadmium sulfide quantum dots coated with maltodextrin (CdS/MD) in Wistar rats. Quantum dots (QDs) are semiconductor nanocrystals (2–100 nm) with unique optical and electrical properties currently applied in biomedical imaging and electronics industries. One of the more valuable properties of QDs is their fluorescence spectrum, which renders them optimal fluorophores for biomedical imaging. Due to the novel characteristics in fluorescence, QDs represent a family of promising substances to be used in experimental and clinical imaging. Thus far, the toxicity and harmful health effects from exposure to QDs are not recognized, but it is necessary to know the possible toxicity of QDs. For this study, we used male and female Wistar rats were administrated intraperitoneally diary with 200 μg/kg CdS/MD QDs. Control rats received vehicle only. Rats were then sacrificed after 15 days, serum, liver, kidney, heart, spleen, lung, thymus, intestines, stomach and brain samples were collected. Tissue samples were fixed in paraffin for H&E stain and others were fixed and analyzed by fluorescence, with the serum of liver and kidney function tests were performed. The results showed no change in the morphological architecture of the organs analyzed. The observation under fluorescence microscopy samples showed a presence QDs of the organ analyzed. There were no changes in the values of serum liver enzymes compared with the control group, as well as kidney function tests. In conclusion, the CdS‐MD QDs do not produce any damage to organs analyzed in male and female rats Wistar.