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Expression and Pharmacological Modulation of Visceral Pain‐Induced Conditioned Place Aversion in Mice
Author(s) -
AlSharari Shakir,
Bagdas Deniz,
Muldoon Pretal,
Carroll Ivy,
Negus Stevens,
Damaj Imad
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.928.6
Subject(s) - analgesic , morphine , ketoprofen , nociception , visceral pain , μ opioid receptor , agonist , pharmacology , medicine , opioid , anesthesia , noxious stimulus , psychology , receptor
Since pain is an unpleasant sensory and emotional experience, to evaluate the negative affective component of visceral pain induced by intraperitoneal (i.p.) noxious acetic acid (AA) injection is important as much as measuring the nociceptive behaviors as seen in stretching. Recent studies showed that i.p. AA resulted conditioned place aversion (CPA) in rats. In this study we first characterized the AA‐CPA in mice, and then we compared the affective and sensory components of pain using well‐known analgesic drugs. AA‐received mice showed CPA in respect to sensorial results which also determined by number of stretches. The nonsteroidal anti‐inflammatory drugs (NSAIDs) ketoprofen, the opioid receptor agonist morphine, and the k ‐opioid receptor agonist U50,488H inhibited the AA‐induced stretching. Ketoprofen and morphine also blocked the AA‐induced CPA but not the U50,488H. The reversal ability of analgesic drugs on CPA is unique to pain‐stimulated place aversion. In respect, ketoprofen and morphine failed to reduce non‐noxious LiCl‐induced CPA. In conclusion, AA‐induced CPA may serve a measure of affective pain sign as pain‐related place aversion, and possible novel analgesic drugs can be test for their effectiveness on affective component of pain in mice.