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Whole Ethanolic Moringa Oleifera Leaf Extract Generates Kinetic Growth Curves of Escherichia coli Comparable to Pharmaceuticals
Author(s) -
Smith Brandon,
Orders Tanner,
Tallapaneni Jetha,
Nair Srijith,
Ravi Vivek,
Emrani Jahangir,
Idassi Joshua,
King James,
Zwetsloot Kevin A.,
Mowa Chishimba
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.921.8
Subject(s) - moringa , escherichia coli , tetracycline , ampicillin , bacterial growth , antibiotics , streptomycin , biology , microbiology and biotechnology , potency , food science , chemistry , bacteria , in vitro , biochemistry , genetics , gene
Premature births are largely caused by preterm infections. Here, we report the anti‐bacterial activities of the medicinal plant Moringa oleifera (M. oleifera) against Escherichia coli (E. coli) , one of the main causes implicated in infections associated with preterm labor. We screened different whole leaf extracts of M. oleifera for anti‐bacterial activities and determined its effects on the overall growth using in vitro kinetic curve liquid broth assays. In our assays, we compared the anti‐bacterial potency of the M. oleifera leaf extracts to commonly utilized antibiotics, such as tetracycline, ampicillin and streptomycin. The pure ethanol leaf extract showed the most anti‐bacterial activity at 20 μg against E. coli , with ethanol and ethanol/water extracts acting in a concentration‐dependent manner, and showed the greatest kinetic change at 6 μg against E. coli and completely inhibited growth, followed by tetracycline at 6 μg compared to control. This study confirms the anti‐bacterial properties of M. oleifera and its potential use as a natural anti‐bacterial agent for the management and prevention of infection‐induced preterm labor. Support or Funding Information Office of Student Research, Appalachian State University.