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Association between Serum Levels of 25‐Hydroxyvitamin and Triglycerides in Patients with Metabolic Syndrome
Author(s) -
Pedrosa Lucia Fatima Campos,
Pereira Hermilla Torres,
Cunha Aline Tuane Oliveira,
Aquino Sephora Louyse Silva,
Lima Severina Carla Vieira Cunha,
Fayh Ana Paula Trussardi,
Lima Josivan Gomes,
SenaEvangelista Karine Cavalcante Maurício
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.917.6
Subject(s) - vitamin d and neurology , medicine , waist , metabolic syndrome , vitamin d deficiency , endocrinology , outpatient clinic , gastroenterology , body mass index , diabetes mellitus
Objective To evaluate the association between serum levels of 25‐hydroxyvitaminD [25(OH)D] and metabolic, nutritional, sociodemographic, and environmental factors in patients with metabolic syndrome (MS). Methods Across‐sectional study included 103 patients (82% women) with MS seen at the endocrinology outpatient clinic of the Onofre Lopes University Hospital, Natal, Northeast Brazil. Biochemical, nutritional, sociodemographic, dietary, sun exposure, and lifestyle variables were measured. Multivariable line arregression was performed to assess associations between serum levels of 25(OH)D and covariates. Results The mean age of patients was 50.2 (SD=13.0) years. The mean 25(OH)D levels were 28.6 (SD=10.4) ng/ml. Approximately 40% and 20 % of patients respectively had insufficient (>20 and<30ng/ml)and deficient (<20ng/ml) levels of 25(OH)D. In the multivariate model(adjusted for age, gender, waist circumference, vitamin D intake, sun exposure, skin phototype, physical activity) 25(OH)D levels were inversely associated with triglycerides (p=0.043). This finding suggests that the increase of 1 mg/dl of triglycerides can reduce 25(OH)D levels by −0.016 ng/ml (95% CI: −0.0307, −0.0004). Conclusion Our results highlight the inverse association between vitamin D and triglycerides independently of the various factors evaluated. Support or Funding Information National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Científico e Tecnológico) – CNPq, Brazil; grant 471761/2013‐3