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The Effect of Vitamin D Supplementation on Blood Lipids in Minorities with Type 2 Diabetes
Author(s) -
Exebio Joel,
Ajabshir Sahar,
Zarini Gustavo,
Huffman Fatma
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.917.4
Subject(s) - medicine , vitamin d and neurology , blood lipids , type 2 diabetes , cholecalciferol , vitamin , pill , diabetes mellitus , gastroenterology , vitamin d deficiency , cholesterol , endocrinology , pharmacology
The aim of the present study was to determine the effect of supplemental vitamin D intake (4000 IU/day or 6000 IU/day of vitamin D 3 over a 6 month period) on blood lipids in a sample of African Americans and Hispanics with type 2 diabetes and vitamin D insufficiency (25(OH)D<30 ng/ml) living in South Florida. Subjects were recruited from two clinics and screened for vitamin D insufficiency. Ninety two participants were screened. Seventy five qualified for the intervention (n=50 for 4000 IU/day treatment and n=25 for 6000 IU/day treatment). Participants in both groups were required to take either 4000 IU or 6000 IU of Cholecalciferol per day given in the form of a pill in a single daily dose. Each participant was seen 4 times; at screening, baseline, 3 months, and 6 months. Serum vitamin D and blood lipids were measured by ELISA. Mixed model was used to compare treatment effects. Bonferroni multiple comparison test was used to detect significant changes over time. Significant changes in serum 25(OH)D levels were seen from baseline to 3 month and 6 months, respectively in both treatments (from 22.25 ± 7.19 to 37.34 ± 12.31 and 37.99 ± 13.22, P <0.05 in the 4000 IU group; from 23.74 ± 5.09 to 43.20 ± 15.94 and 40.62 ± 19.39, P <0.05 in the 6000 IU group). A significant decrease in total cholesterol (from 193.88 ± 41.03 to 180.48 ± 27.53 mg/dl, P =0.040) and triglycerides (from 201.44 ± 91.35 to 172.92 ± 76.87 mg/dl, P =0.037) was found for the 6000 IU group at 6 months. The significance was lost after adjusting for confounders. The positive effect of vitamin D supplementation on blood lipids may be mediated by other cofactors related to vitamin D metabolism. Support or Funding Information Funding for this research was provided through a grant from NIH/NIDDK