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Homeostatic model assessment index 1 and 2 are associated with serum 25‐hydroxyvitamin D among Haitians and African‐Americans living in South Florida
Author(s) -
Ajabshir Sahar,
Exebio Joel,
Zarini Gustavo,
Voccaro Joan,
Huffman Fatma
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.917.12
Subject(s) - insulin resistance , homeostatic model assessment , medicine , vitamin d and neurology , vitamin d deficiency , type 2 diabetes , endocrinology , diabetes mellitus , metabolic syndrome , insulin
Purpose The purpose of this study was to investigate the association between insulin resistance calculated by homeostatic model assessment index 1 (HOMA1‐IR), homeostatic model assessment index 2 (HOMA2‐IR) and serum 25‐hydroxyvitamin D [25(OH)D] among a group of Haitian‐Americans and African‐Americans living in South Florida. Significance Low serum vitamin D level is associated with a wide range of health concerns such as diabetes, osteomalacia, auto‐immune disorders and certain cancers. Several studies indicated higher insulin resistance is associated with increased risk of developing metabolic syndrome and type 2 diabetes. There are currently no studies investigating the relationship between vitamin D and insulin resistance among Haitian‐Americans and African‐Americans. Participants The sample for this study included 241 participants without type 2 diabetes, Haitian Americans (n= 124) and African‐Americans (n= 117), ages 35–82 years. Design and methodology In a cross‐sectional study participants were recruited from Miami‐Dade and Broward counties, Florida. Serum 25(OH)D, total cholesterol, triglycerides and C‐reactive protein were measured by ELISA method. HOMA1‐IR was calculated by the formula HOMA1‐IR=[fasting plasma insulin (μU/ml) × fasting plasma glucose (mmol/L)]/22.5 and HOMA2‐IR values were determined by an online calculator. Vitamin D and calorie intakes were calculated from a validated food frequency questionnaire. Multi‐linear regression models were run, adjusting for age, gender, ethnicity, serum total cholesterol, triglycerides, C‐reactive protein, systolic blood pressure, vitamin D and daily calorie intakes, smoking and alcohol consumption. HOMA1‐IR and HOMA2‐IR were the dependent variables. Data analysis and results The mean age was 52.37±9.96 years. The mean serum 25(OH)D, HOMA1‐IR and HOMA2‐IR were 22.91±8.55 ng/ml, 2.88±2.09 and 1.51±1.02, respectively. Serum 25(OH)D was negatively correlated with HOMA1‐IR (r=−.147, P =.023) and HOMA2‐IR (r=−.143, P =.027). Multi‐linear regression analyses controlling for the covariates indicated a significant negative association between serum 25(OH)D and HOMA1‐IR (B=−.038, P =0.012) as well as HOMA2‐IR (B=−.019, P =0.009). These models explained 20.2% of the variation in HOMA1‐IR and 18% of the variation in HOMA2‐IR. Conclusion Lower serum 25(OH)D is associated with higher insulin resistance calculated by both HOMA1‐IR and HOMA2‐IR methods. Presence of insulin resistance may be predictive of vitamin D insufficiency. Support or Funding Information Funding source: Funding for this research was provided through a grant from NIH/NIDDK.