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Anti‐inflammatory Effect of Black Adzuki Bean in High Fat Diet Induced Obese Mice
Author(s) -
Yook JinSeon,
Kim Mina,
Kim KyungAh,
Cha YounSoo
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.916.11
Subject(s) - inflammation , obesity , medicine , endocrinology , appetite , chemistry , biology
High‐fat diet induced obesity promotes low‐grade inflammation and becomes root cause for several metabolic diseases. Adzuki bean ( Vigna angularis ), has been reported to possess several health benefits including anti‐obesity and anti‐inflammatory effects. Our recent study elucidated that black adzuki bean (BAB) was effective in inhibiting adipogenic process in cell lines and regulating appetite in rodents. Hyperphagia triggers hypertrophy of adipocytes leading to inflammation. As our previous study suggested that BAB regulate appetite in rodents; therefore, we hypothesized that the intake of black adzuki bean may improve obesity induced inflammation. The aim of this study was to investigate the anti‐inflammatory role of BAB on high fat diet induced obese mice. C57BL/6J mice were divided into 4 groups: Normal Diet (ND), High‐fat Diet (HD), High‐fat diet with 1% BAB extract (BAB), High‐fat diet with 0.08% Kaempferol (Kfr). After the completion of 12 weeks of treatment, several parameters including body composition and inflammatory markers were examined. The body weight, fat and liver weight were significantly lower in BAB and Kfr treated groups compared to HD group. In addition, parameters related to the inflammation were also improved in BAB and Kfr treated groups. Alterations of body composition and lowered pro‐inflammatory cytokines suggested that BAB might have anti‐inflammatory effects against high‐fat induced obesity in mice.