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Predictive modeling of child obesity according to salt‐sensitive genes and sodium intakes in Korean children; the 3 year‐Panel Study
Author(s) -
Park Jiae,
Bak Sujeong,
Park Soyoung,
Lee Myoungsook
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.911.1
Subject(s) - obesity , overweight , medicine , percentile , waist , sodium , body mass index , endocrinology , zoology , demography , biology , chemistry , mathematics , statistics , organic chemistry , sociology
Goals This study was performed to predict obesity in Korean children according to the sodium intake and 9 salt‐sensitive genes(GRK4 A142V, SLC12A3, CYP11β‐2, GRK4 A486V, NEDD4L, AGT M235T, GNB3 C285T, ADD1 G460W, ACE) selected from GWAS. Methods In 2007(n=1091) and 2009(n=1045), 2,136 Korean children aged 9 years were recruited from 8 elementary schools in Seoul, and 979(45.83%) of total subjects were followed‐up at 12 years old in 2010 and 2012. Chi‐square test, Student's unpaired t‐test and Student's paired t‐test were used to compare the differences between obesity(OB) and non‐OB or before and after 3 years. Tests for Hardy‐Weinberg equilibrium for each SNPs were conducted by comparing the observed and expected genotype frequencies with Chi‐square test. Obesity was defined as BMI ≥ 85th percentile and energy‐adjusted sodium intake was used by residual methods as sodium intake in each year. Results Among the non‐OB children aged 9, the indicators such as waist, HDLc, retinol, vit B2 and cholesterol intakes were significantly different between OB and non‐OB children at 12 years old. The average differences of sodium intakes were not significant between OB and non‐OB. However, the obesity prevalence was significantly lower in lowest quintile(Q1) of sodium intake than that in group of 2 nd to 5 th quintile(Q2–Q5).(p=0.008) The relative frequencies of OB including overweight were significantly higher in Hetero & Mutant of NEDD4L than that in wild genotypes.(p=0.02) No other genes were found the differences in frequencies of OB or non‐OB among their genotypes. Conclusions The non‐OB children, aged 9 years old, sustained non‐OB at 12 years old tend to reduce sodium intake considerably and wild type of NEDD4L was profoundly frequent in those children. Wild genotype of NEDD4L and reduction of sodium intake might be associated with prevention of obesity in Korean children. In future, our panel data may be applied for the individualized obesity prediction model to reduce children obesity. Support or Funding Information This work was supported by National Research Foundation of Korea(NRF) grant funded by the Korea government(MEST) (NRF‐2015R1A2A1A11049611) and This work is supported by Korea Food Research Institute.