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Microfluidic Systems for Stem Cell Studies
Author(s) -
Tayebi Lobat
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.91.3
Subject(s) - microfluidics , stem cell , mesenchymal stem cell , nanotechnology , microbiology and biotechnology , stem cell niche , cellular differentiation , cell , biology , materials science , progenitor cell , biochemistry , genetics , gene
Stem‐cell therapies have the potential to revolutionize the healthcare. Microfluidic‐assisted systems can be used for cell‐based assays to provide unique information about the cellular behavior of stem cells. The significance of microfluidic platforms is their ability to mimic the in vivo microenvironment. Moreover, using microfluidic systems, the quantity and level of different agents and cell stimulator factors can be controlled. Such precise controlling is highly important for stem cell culturing and differentiation. It is known that to employ stem cells in clinical applications, the key challenge is scaling up the cultures in large bioreactors for master banking of stem cells to be used for treatment of patients. Thus, small microfluidics system is useless for this purpose. However, many technical problems in the important task of controlling stem cell growth and differentiation can be answered using the precise microfluidic systems. In this talk, after presenting a discussion on the application of microfluidic platforms in stem cell culturing and differentiation, the latest developed microfluidic systems for stem cell study will be introduced. This includes our group's recent innovation in designing a microfluidic platform for regulating the osteogenic differentiation of mesenchymal stem cells (MSCs).