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Dietary supplementation with chia ( Salvia hispanica L.) oil reduces the complications caused by high fat diet‐induced obesity
Author(s) -
Citelli Marta,
FonteFaria Thaís,
VargasSilva Simone,
BarjaFidalgo Christina
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.907.20
Subject(s) - leptin , medicine , endocrinology , polyunsaturated fatty acid , adipose tissue , insulin resistance , steatosis , weaning , insulin , chemistry , lipid metabolism , lipid profile , alpha linolenic acid , fatty acid , biology , obesity , cholesterol , biochemistry , docosahexaenoic acid
Changes in insulin sensitivity may be promoted by non‐esterified fatty acids and inflammatory cytokines, commonly present in obesity. Because they are directly related to adipogenesis and energy metabolism, various fatty acids have been correlated to the consequences of obesity, especially some of the polyunsaturated omega‐3, which may be substrates for the synthesis of inflammatory mediators such as resolvins and neuroprotectinas. Recently, it was reported that chia seed oil (ChO) is the richest vegetable source of fatty acid alpha‐linolenic (ALA, 18: 3 n‐3). Thus, the present study aimed to evaluate the effects of ChO dietary supplementation on an animal model of high fat diet (HFD) induced metabolic syndrome. For this, C57BL/6 mice were fed a HFD from weaning. They received the ChO supplementation from 90 to 135 days of life. Every 2 days the diet was replaced to prevent the oxidation of lipids. Plasma insulin, leptin and TNF‐alpha levels were assessed by ELISA. The insulin signaling pathways within muscle tissue was assessed by Western blotting analyses. Fatty acids and lipid profiles were determined by gas chromatography. Our data demonstrated that ChO supplementation did not change the total weight, but changed the lipid profile in liver and adipose tissue, decreased leptin, triglycerides, insulin and hepatic cholesterol. It also improved insulin resistance through activation of the signaling cascade. Although ChO supplementation promoted positive effects, it appears that these were not mediated by inflammation resolution, since no changes in the systemic inflammatory parameters were observed.