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Iodine Status Is Associated with Dyslipidemia in US Adults
Author(s) -
Lee Kyung Won,
Shin Dayeon,
Cho Mi Sook,
Song Won O.
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.904.9
Subject(s) - dyslipidemia , medicine , iodine , odds ratio , endocrinology , national health and nutrition examination survey , population , iodine deficiency , thyroid function , cholesterol , logistic regression , apolipoprotein b , thyroid , chemistry , obesity , environmental health , organic chemistry
Iodine is an essential component of thyroid hormone which plays crucial roles in healthy thyroid function and affects lipid metabolism. The association between iodine status and dyslipidemia has not been well established at a population level. We aimed to test the association between iodine status and the prevalence of dyslipidemia including elevated total and LDL cholesterol, triglycerides, and apolipoprotein B, and lowered HDL cholesterol and HDL/LDL ratio. National representative data of 2,495 US adults (≥20 years) in National Health and Nutrition Examination Survey 2007–2012 were used. Iodine status, assessed by urinary iodine concentration criteria of WHO/UNICEF/ICCIDD, and dyslipidemia defined based on NCEP ATP III guidelines were associated by chi‐square test and linear and multiple logistic regression. Serum lipids biomarkers were significantly associated with iodine status when controlling for sociodemographic covariates (all, P <.05). Those with <50 μg/L UIC (moderate‐to‐severe iodine deficiency) were more likely to be at risks for elevated total cholesterol (>200 mg/dL) (adjusted odds ratio [AOR]=1.52, 95% CI: 1.03–2.25) and LDL cholesterol (>130 mg/dL) (AOR=1.58, 95% CI: 1.11–2.23) and lowered HDL/LDL ratio (<0.4) (AOR=1.41, 95% CI: 1.01–1.96), compared to those with 100–199 μg/L UIC (iodine adequacy). In US adults, moderate‐to‐severe iodine deficiency was associated with increased odds for dyslipidemia. Our findings of association between iodine status and serum lipids may provide insight into efficient way to decrease risks of dyslipidemia before thyroid dysfunction due to insufficient iodine intake produce serum lipid abnormalities. Further investigations are warranted to elucidate the causal relationship and the potential mechanism of the interaction between iodine status and serum lipid profiles.