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Postprandial Blood Glucose Level Reducing Effect of Low Molecular weight Chitosan Oligosaccharide, GO2KA1, in Health Individuals
Author(s) -
Kang YuRi,
Choi HwangYong,
Lee JungYun,
Oh JungBae,
Kim Justin S.,
Lee JongWook,
Kim YoungCheul,
Apostolidis Emmanouil,
Kwon YoungIn
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.903.4
Subject(s) - postprandial , medicine , meal , carbohydrate , endocrinology , ingestion , chemistry , area under the curve , insulin
We evaluated the effects of chitosan oligosaccharide (GO2KA1) on the level of postprandial blood glucose in adult subjects with normal blood glucose level. Postprandial blood glucose levels were tested for 2 hr after bread ingestion with or without 600 mg of GO2KA1. As a result, GO2KA1 significantly lowered the mean, maximum and minimum level of postprandial blood glucose at 30 min after meal. Postprandial blood glucose levels were decreased by about 25% (from 155.11 ± 13.06 to 138.50 ± 13.59, p <0.01) at 30 min when compared to control. Furthemore, we observed that AUC t was decreased by about 6% (from 255.46 ± 15.43 to 240.15 ± 14.22, p <0.05) and C max was decreased by about 11% (from 157.94 ± 10.90 to 140.61 ± 12.52, p <0.01) while T max was equal when compared to control. Our findings suggest that GO2KA1 reduces postprandial blood glucose rise due to low absorption of glucose in the small intestine, via carbohydrate hydrolyzing enzymes inhibition.