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Plasma Amino Acids and Mortality in a Middle‐Aged and Older Chinese Population during 6‐year Follow‐up
Author(s) -
Sun Liang,
Lin Xu,
Zeng Rong
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.902.15
Subject(s) - medicine , hazard ratio , population , isoleucine , amino acid , phenylalanine , diabetes mellitus , cystine , endocrinology , physiology , leucine , chemistry , confidence interval , biochemistry , environmental health , cysteine , enzyme
Recently, circulating amino acids, especially branched‐chain species, are found to be associated with risks of metabolic diseases. However, little is known about their associations with mortality in community‐based population, especially in Asians. Therefore, the current study was aimed to investigate the associations of plasma amino acids with total and cerebrovascular and cardiovascular mortality in a middle‐aged and older Chinese population. A total of 2,082 participants aged 50–70 years from Beijing and Shanghai, China were followed up for 6 years, and 99 of them were deceased during follow‐up. Baseline plasma amino acids were quantified by gas chromatography‐mass spectrometry (GC/MS). Higher baseline concentrations of plasma histidine, cystine, isoleucine, proline and ornithine were found among deceased individuals than their alive counterparts. In the cox proportional hazard model, after adjusting for demographic and lifestyle information, family history of chronic diseases, baseline diabetes, hypertension, coronary heart disease and stroke, as well as BMI, blood lipids profile and inflammatory markers, elevated plasma cystine, isoleucine, proline and ornithine were significantly associated with increased total mortality, and the hazard ratios per SD increase were 1.15 (95% CI 1.02–1.31), 1.34 (95% CI 1.05–1.71), 1.42 (95% CI 1.15–1.75) and 1.38 (95% CI 1.15–1.65), respectively. Moreover, after categorized by cause of death, plasma cystine, isoleucine, proline, phenylalanine and ornithine were found to be positively associated with cerebrovascular and cardiovascular mortality after multiple adjustments ( P <0.05). In conclusion, accumulation of specific amino acids may increase the risks of total and cerebrovascular and cardiovascular mortality in middle‐aged and older Chinese adults. Support or Funding Information Our study was supported by The Ministry of Science and Technology of China (2012CB524900) and National Natural Science Foundation of China (81321062).