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Higher Diet Quality and Decreased Inflammation in Young Women
Author(s) -
Chen Qiong,
Cramoy Carolyn C,
Magner Raymond,
Ronnenberg Alayne G,
BertoneJohnson Elizabeth R,
Troy Lisa M
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.902.12
Subject(s) - medicine , inflammation , national health and nutrition examination survey , body mass index , disease , population , environmental health
Inflammation is associated with chronic disease risk such as Type‐2 diabetes mellitus, cardiovascular disease, and cancer. A primary aim of the 2010 Dietary Guidelines for Americans (DGA) is to prevent chronic diseases through recommendations that emphasize a high quality diet. We previously showed that following a diet consistent with the DGA was associated with lower inflammation among middle‐aged men and women. Few studies have examined overall diet quality and inflammation status in young adults. We therefore examined cross‐sectional associations between diet quality and fasting plasma Interleukin‐6 (IL‐6), a biomarker of chronic inflammation, among 183 young women (mean age=21 years) from the UMass Vitamin D Status Study. Dietary data were collected using a modified Harvard Food Frequency Questionnaire. Diet quality was assessed using the 2010 Dietary Guidelines for Americans Adherence Index (DGAI‐2010). The DGAI‐2010 has a possible range of 0 (least) to 100 (best) adherence to the DGA (mean=68.6; range 42.6 to 81.7). IL‐6 levels from fasting blood samples were determined by a multiplex bead‐based suspension array (AssayGate, Inc. Ijamsville, MD) and were log transformed (range 0 to 4.5 pg/mL) to normalize for statistical analysis. Using multivariable linear regression, we observed an inverse association between DGAI‐2010 quintile categories and IL‐6, after adjusting for smoking (ever vs never), NSAID use (yes vs no), and BMI (continuous) (p‐trend=0.02). Mean IL‐6 levels decreased (3.3, 2.8, 2.6, 2.0, and 1.6 pg/mL respectively) across increasing DGAI‐2010 quintile categories. Following a diet that is consistent with the 2010 DGA as a measure of diet quality is associated with lower inflammation among young women.