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Sarcopenic Obesity in Women with Polycystic Ovary Syndrome: Effect of a Pulse Based‐Diet and Exercise Intervention
Author(s) -
McBreairty Laura E,
Zello Gordon A,
Gordon Julianne J,
Chizen Donna R,
Chilibeck Philip D
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.893.1
Subject(s) - polycystic ovary , medicine , sarcopenic obesity , obesity , lean body mass , infertility , population , endocrinology , insulin resistance , sarcopenia , gynecology , pregnancy , body weight , biology , environmental health , genetics
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and leads to an increased risk of heart disease, diabetes, infertility and endometrial cancer. Sarcopenic obesity is a term used to describe low appendicular skeletal muscle mass (ASM) relative to total body mass and, although most commonly associated with the aging population, women with PCOS share many of the characteristics associated with this condition including increased visceral adiposity, chronic inflammation and insulin resistance. We hypothesized that a pulse‐based diet (e.g. beans, lentils) would have a positive effect on body composition as analyzed by dual energy X‐ray absorptiometry. Sixty‐seven women with PCOS aged 18–35y were enrolled in the study with 44 completing the randomly assigned intervention of either a pulse‐based diet (n=25) or the National Cholesterol Education Program (NCEP) therapeutic lifestyle changes (TLC) diet (n=19) for 16 wk while participating in an exercise program. At baseline, the average % ASM was 24.2 ± 3.1% and 56% of women with PCOS were classified as sarcopenic obese as defined by having a % ASM 2 standard deviations below the mean for healthy young females studied by our group (30.4 ± 3.2%; n=14). Following the intervention, BMI was lower in both groups (p<0.001; Pulse −1.0 vs TLC −0.7) as well as percent fat mass (p<0.005; Pulse −0.5 vs TLC −0.8 %). Although there were no changes in lean body mass following the intervention, % ASM was higher in both groups (p<0.005; Pulse +1.0 vs TLC +1.3 %), suggesting that a pulse based diet is equally effective as the TLC diet when combined with exercise to reduce the prevalence of sarcopenic obesity in women with PCOS. Support or Funding Information Supported by the Saskatchewan Pulse Growers, Agriculture Agri‐Food Canada (Cluster Program) and Saskatchewan Health Research Foundation