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Oral Contraceptive Use is Associated with Increased Serum 25‐hydroxyvitamin D and Decreased Serum Parathyroid Hormone but not with Bone Mass Status in Young Adult Uruguayan Women
Author(s) -
Cornes Rafael,
Peña Amparo,
Donangelo Carmen Marino
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.892.3
Subject(s) - medicine , endocrinology , parathyroid hormone , bone mineral , femoral neck , creatinine , vitamin d and neurology , calcium metabolism , calcium , chemistry , osteoporosis
Use of oral contraceptives (OC) has been shown to increase serum 25‐hydroxyvitamin D [25(OH)D] but effects on calcium and bone homeostasis remain unclear. In this study, we compared serum 25(OH)D, parathyroid hormone (PTH) and alkaline phosphatase activity (ALK), urinary calcium and potassium as creatinine molar ratios, and bone mass status of young adult Uruguayan women (20–35 y; BMI, 21.5 ± 2.3 kg/m 2 ), users (+OC, n=32) and non‐users (−OC, n=20) of OC. Serum 25(OH)D and intact PTH were determined by chemiluminescent assays. Bone mineral content (BMC) and density (BMD) at total body (TB), lumbar spine (LS), femoral neck (FN) and trochanter (TR) were measured by dual energy X‐ray absorptiometry. Mean serum 25(OH)D concentration was 35% higher in +OC (32.7 ± 2.3 ng/mL) compared to − OC (44.2 ± 1,8 ng/mL) (p<0.001) whereas mean serum PTH, serum ALK and urinary potassium were 28%, 12% and 35% lower, respectively, in +OC compared to −OC (p<0.05). Mean Z scores of bone measurements were adequate in the whole group [TBBMC, 0.70 ± 0.86; TBBMD, 0.44 ± 0.73; LSBMD, 0.076 ± 0.92; FNBMD, −0,194 ± 0.78; TRBM, −0.570 ± 0.94) with no significant differences between +OC and −OC (p>0.20). Our results indicate that use of OC is associated with increased circulating levels of 25(OH)D in the women studied, as previously described in other populations. Use of OC was also associated with changes in biochemical indices of calcium homeostasis consistent with decreased bone turnover. The use of OC should be considered when evaluating calcium and bone homeostasis in relation to vitamin D status.