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Self‐organization of zebrafish lateral line primordium morphogenesis and migration
Author(s) -
Chitnis Ajay,
Nogare Damian Dalle
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.8.2
Subject(s) - primordium , zebrafish , morphogenesis , lateral line , microbiology and biotechnology , biology , live cell imaging , wnt signaling pathway , anatomy , developmental biology , cell , signal transduction , genetics , gene
The zebrafish Posterior Lateral Line Primordium (PLLp) pioneers the establishment of the Posterior Lateral Line system. Interactions between the Wnt, FGF, Notch, and chemokine pathways in the PLLp provide a framework for understanding how cell fate and morphogenesis are coordinated in this group of about a hundred cells, as they collectively migrate under the skin from the ear to the tip of the tail. We have used a combination of experiment and computational modeling to define the mechanisms that determine both the periodic formation of neuromasts and their deposition along with inter‐neuromast cells, as the PLLp migrates along a path defined by chemokine expression. Furthermore, our high resolution imaging of the morphology and dynamics of individual cells in the primordium reveal unexpected features of how cells with distinct morphologies in distinct parts of the PLLp contribute to collective migration and communication between leading and trailing cells in the primordium. Together, our studies reveal novel features of the self‐organization of this remarkable system. Support or Funding Information Eunice Kennedy Shriver National Institute of Child Health and Human Development intramural Program