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Effect of electroacupuncture on cardiac excitability during sympathoexcitation induced by acute ischemia and left stellate ganglion stimulation in a porcine model
Author(s) -
Zhou Wei,
Takamiya Tatsuo,
Yamamoto Kento,
Mahajan Aman
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.754.1
Subject(s) - electroacupuncture , stellate ganglion , medicine , cardiology , heart rate variability , anesthesia , ischemia , stimulation , heart rate , blood pressure , acupuncture , alternative medicine , pathology
Augmentation of cardiac sympathetic tone during myocardial ischemia has been shown to increase myocardial O2 demand and infarct size as well as induce arrhythmias. We have previously demonstrated that electroacupuncture (EA) mitigates myocardial ischemia‐reperfusion injury by modulation of cardiac norepinephrine release. The purpose of this study is to determine the effects of EA on cardiac excitability evaluated by measurement of activation recovery interval (ARI) and heart rate variability (HRV) by using power spectral analysis. A median sternotomy was performed to expose the heart and the left stellate ganglion (LSG). Acute myocardial ischemia (AMI) was induced by ligation of left descending coronary artery. A 56‐electrode was placed on the heart to record ARI, a surrogate measure of action potential duration. AMI with LSG stimulation significantly shortened ARI by 5.4% and increased dispersion by 160% as well as increased LF/HF from 0.31 to 1.18 (n.u.). 30 min of EA significantly attenuated the ARI shortening (1.7% vs. 5.4%) and dispersion (104% vs. 160%) as well as decreased the LF/HF from 1.18 to 0.70 (n.u.) with decreased LF components from 46.5±3.5 to 27.2±4.1(n.u.) and increased HF components from 38.5 to 49.2 (n.u.). In conclusion, EA modulates the cardiac excitability through inhibition of sympathetic nerve system and activation of parasympathetic nerve system. Support or Funding Information Department Fund