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Effects of Acute Induced Inflammation on Arterial Stiffness and Compliance in Overweight Adults
Author(s) -
Bunsawat Kanokwan,
LaneCordova Abbi Danielle,
Fernhall Bo,
Baynard Tracy
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.737.5
Subject(s) - medicine , arterial stiffness , pulse wave velocity , inflammation , blood pressure , supine position , cardiology , overweight , interleukin 6 , compliance (psychology) , heart rate , carotid arteries , systemic inflammation , c reactive protein , obesity , psychology , social psychology
Changes in the elastic properties of the large arterial wall have been associated with increased cardiovascular risk. Excess body weight can contribute to changes in the elastic properties and may manifest initially as blood pressure (BP) elevations. Acute induced inflammation has also been shown to transiently reduce the elastic properties of large arteries. It remains unclear whether acute induced inflammation has an additive effect of dampening vascular compliance in overweight (OW) adults. Our objective was to investigate the effect of acute induced inflammation (influenza vaccine) on arterial compliance in young normal weight (NW) vs. OW adults at baseline and 24‐hr and 48‐hr post‐vaccination. Subjects were 19 NW (26±1 yrs; 21.4±0.4 kg/m 2 ) and 16 OW (25±1 yrs; 26.7±0.4 kg/m 2 ). Carotid BP and central pulse wave velocity (cPWV) were measured in the supine position using applanation tonometry. Carotid intima‐media thickness (cIMT), arterial compliance (AC) and elastic modulus (EP) measurements were obtained from the common carotid artery using ultrasonography. Interleukin‐6 (IL‐6) and C‐reactive protein (CRP) were measured using ELISA assays. No group difference was found for cIMT (0.38±0.01 vs. 0.42±0.02 mm in NW and OW, respectively). Carotid BP was higher in OW than in NW at all time points (P<0.05), without any acute inflammation effect. Acute inflammation increased heart rate, IL‐6, and CRP similarly in both groups ( P <0.05). An interaction in AC approached significance ( P =0.055), such that AC increased in NW and decreased in OW at 24‐hr before returning to baseline value at 48‐hr. Our results demonstrated that despite elevations in carotid BP with excess body weight, no additive effect is seen with acute inflammation in OW, suggesting preserved vascular responsiveness in this young cohort. However, a larger sample size would help definitively determine the effects.Variables Baseline 24‐hr post 48‐hr post Time Interaction GroupHeart Rate (bpm) NW 57±2 59±2 56±2 0.047 0.881 0.632 OW 59±2 60±2 57±2 Carotid SBP (mmHg) NW 107±4* 110±3 108±3 0.666 0.698 <0.001OW 126±4 126±3 125±3 Carotid DBP (mmHg) NW 61±2* 59±2 60±2 0.116 0.981 0.020OW 67±2 64±2 67±2 Carotid MAP (mmHg) NW 79±2* 80±2 78±2 0.279 0.702 <0.001OW 88±2 88±2 86±2 Carotid PP (mmHg) NW 46±4* 51±3 48±3 0.311 0.658 0.012OW 59±4 60±3 59±4 AC (mm 2 /kPa) NW 1.47±0.16 1.51±0.10 1.29±1.11 0.593 0.055 0.187 OW 1.37±0.18 1.05±0.12 1.23±0.13 Ep NW 54.1±6.5 44.4±4.4 55.6±5.0 0.871 0.351 0.148 OW 56.6±7.8 62.7±5.2 55.3±6.0 cPWV (m/s) NW 5.2±0.2 5.4±0.2 5.5±0.2 0.479 0.877 0.053OW 5.9±0.3 6.0±0.2 5.8±0.3 IL‐6 NW 0.94±0.15 1.86±0.46 0.87±0.28 <0.001 0.721 0.493 OW 0.97±0.16 2.41±0.48 1.32±0.28 CRP NW 1.26±0.30 1.92±0.48 2.46±0.65 <0.001 0.768 0.812 OW 0.77±0.31 1.93±0.49 2.65±0.67Data are mean±SE. SBP, systolic blood pressure; DBP, diastolic blood pressure: MAP, mean arterial pressure; PP, pulse pressure; AC, arterial compliance; Ep, elastic modulus; cPWV, central pulse wave velocity; IL‐6, interleukin‐6; CRP, C‐reactive protein.